ZINC ACETATE AS AN EFFICIENT CATALYST FOR THE SYNTHESIS OF SUBSTITUTED QUINAZOLINONES

Authors

  • Vaygavkar School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606, Maharashtra, India
  • Makone School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606, Maharashtra, India

DOI:

https://doi.org/10.55434/CBI.2025.10102

Keywords:

Aldehydes, dimedone, Zn(OAc)2•2H2O, Biginelli-type, quinazolinones, Lewis acid, multi-component reactions

Abstract

We successfully developed an effective and sustainable synthesis of a number of substituted quinazolinone derivatives using a one-pot multi-component Biginelli type condensation reaction of aromatic aldehydes, urea, and dimedone in the presence of Zn(OAc)2•2H2O as a Lewis acidic catalyst in toluene under reflux conditions. This low-cost, environmentally friendly methodology has several advantages, including high catalytic activity, great yields, convenience of use, a wide range of functional group tolerance, and a column-free approach.

Author Biographies

Vaygavkar, School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606, Maharashtra, India

Research Scholar, School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606, Maharashtra, India

Makone, School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606, Maharashtra, India

Professor, School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606, Maharashtra, India

Downloads

Published

31-12-2025

How to Cite

Vaygavkar, A. M. ., & Makone, S. S. . (2025). ZINC ACETATE AS AN EFFICIENT CATALYST FOR THE SYNTHESIS OF SUBSTITUTED QUINAZOLINONES. Caribbean Journal of Sciences and Technology, 13(1), 21–27. https://doi.org/10.55434/CBI.2025.10102

Issue

Vol. 13 No. 1 (2025)

Section

Research Article
Crossref
Scopus
Google Scholar
Europe PMC